| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738493 | Free Radical Biology and Medicine | 2011 | 9 Pages |
Abstract
⺠Mitochondrial dysfunction impairs lymphocyte homeostasis in occult HCV infection. ⺠Oxidative stress exerts PI3 kinase mediated nuclear DNA damage response. ⺠Occult hepatitis C infection triggers premature apoptosis of lymphocytes. ⺠We explain the immune pathogenesis of HCV infection in a redox dependent manner.
Keywords
p-p53PatrPI3-kinaseDSB5-(and-6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate acetyl esterSVRFITCCM-H2DCFDA8-oxo-dGDcfALTARP2′,7′-dichlorofluorescin8-oxo-2′-deoxyguanosineROSalanine transferaseEDTAEthylenediaminetetraacetic acidDNA repairApoptosismtDNAFree radicalsSODSuperoxide dismutaseendoplasmic reticulumdouble-strand breakphycoerythrinPhosphoinositol 3-kinasefluorescein isothiocyanateHepatitis C virusHCVpolymerase chain reactionPCRsustained virological responsePatmTranslational researchglutathione reductaseReactive oxygen species
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Authors
Arpit Bhargava, Gorantla V. Raghuram, Neelam Pathak, Subodh Varshney, Suresh K. Jatawa, Deepika Jain, Pradyumna K. Mishra,