Mitochondrial respiratory chain and free radical generation in stroke

Article ID	Journal	Published Year	Pages	File Type
10739514	Free Radical Biology and Medicine	2005	14 Pages	PDF

Abstract

This review is focused on the role of the mitochondrial respiratory chain as both source and target of reactive oxygen and nitrogen species such as nitric oxide, superoxide and peroxynitrite produced in cerebral ischemia. The neuroprotective role of antioxidants or other molecules acting on the mitochondrial respiratory chain and ATP synthesis in the setting of cerebral ischemia is discussed.

Keywords

TNF-α-converting enzyme NOS HIF-1 PLA2 TACE MPT NMDA N-methyl-d-aspartate COX LPS NF-κB neuronal NOS inducible NOS ATP Antioxidants cyclooxygenase phospholipase A2 membrane permeability transition endothelial NOS Oxidants Ischemia Electron paramagnetic resonance EPR tumor necrosis factor-α Free radicals SOD Superoxide dismutase Stroke hypoxia inducible factor-1 interferon regulatory factor-1 TNF-α nuclear factor kappa B lipopolysaccharide CSF Cerebrospinal fluid Neuroprotection Mitochondria Nitric oxide nitric oxide synthase