Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10739585 | Free Radical Biology and Medicine | 2005 | 7 Pages |
Abstract
The synergistic antioxidant mechanism of α-tocopherol (vitamin E) with green tea polyphenols, i.e., (â)-epicatechin (EC), (â)-epigallocatechin (EGC), (â)-epicatechin gallate (ECG), (â)-epigallocatechin gallate (EGCG), and gallic acid (GA), was studied by assaying the kinetics of the reaction of α-tocopheroxyl radical with green tea polyphenols by stopped-flow electron paramagnetic resonance, the inhibition of linoleic acid peroxidation by these antioxidants, and the decay of α-tocopherol during the peroxidation. It was found that the green tea polyphenols could reduce α-tocopheroxyl radical to regenerate α-tocopherol with rate constants of 0.45, 1.11, 1.31, 1.91, and 0.43 à 102 Mâ1 sâ1 for EC, EGC, ECG, EGCG, and GA, respectively, in sodium dodecyl sulfate micelles. In addition, these second-order rate constants exhibited a good linear correlation with their oxidation potentials, suggesting that electron transfer might play a role in the reaction.
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Authors
Bo Zhou, Long-Min Wu, Li Yang, Zhong-Li Liu,