Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10744949 | Parkinsonism & Related Disorders | 2015 | 8 Pages |
Abstract
LRRK2 silencing is well tolerated in mouse, arguing PD does not result from LRRK2 loss of function. High levels of WT and G2019S LRRK2 produce similar but temporally distinct phenotypes, potentially modeling different stages of disease progression. The data implicate gain of LRRK2 function in the pathogenesis of PD.
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Authors
Mattia Volta, Stefano Cataldi, Dayne Beccano-Kelly, Lise Munsie, Igor Tatarnikov, Patrick Chou, Sabrina Bergeron, Emma Mitchell, Roscoe Lim, Jaskaran Khinda, Alejandro Lloret, C.Frank Bennett, Carmela Paradiso, Michele Morari, Matthew J. Farrer,