Use of metabotropic glutamate 5-receptor antagonists for treatment of levodopa-induced dyskinesias

Animal model studies provide evidence for anti-dyskinetic efficacy of metabotropic glutamate 5-receptor antagonists. Initial proof-of-concept clinical trials of mavoglurant and dipraglurant showed positive results; anti-dyskinetic efficacy was not supported by two recent mavoglurant trials. Further evaluations of optimal dosage and long-term efficacy and safety of metabotropic glutamate 5-receptor antagonists for management of l-Dopa-induced dyskinesias in Parkinson's disease are required.