Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10745479 | Parkinsonism & Related Disorders | 2013 | 7 Pages |
Abstract
In the preclinical stage of SCA2 parkinsonism, the connectivity of a part of the basal ganglia motor loop is weakened as a consequence of dopaminergic deficits; meanwhile, the connectivity of other large-scale brain networks is strengthened presumably to compensate for the dysfunction of the basal ganglia to maintain brain function in the early stage of dopaminergic deficits. The simultaneous effects of progressive disruption of basal ganglia motor circuits and failure of compensatory mechanisms as dopaminergic dysfunction progresses may contribute to the onset of clinical symptoms.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Tao Wu, Chaodong Wang, Jue Wang, Mark Hallett, Yufeng Zang, Piu Chan,