Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10745528 | Parkinsonism & Related Disorders | 2014 | 5 Pages |
Abstract
Our findings support the relationship between levodopa and PN and confirm that an imbalance in VB12/hcy may be a key pathogenic factor. We suggest two different, possibly overlapping mechanisms of PN in patients on CDLII: axonal degeneration due to vitamin deficiency and inflammatory damage. Whether inflammatory damage is triggered by vitamin deficiency and/or by modifications in the intestinal micro-environment should be further explored. Proper vitamin supplementation may prevent peripheral damage in most cases.
Keywords
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Authors
F. Mancini, C. Comi, G.D. Oggioni, C. Pacchetti, D. Calandrella, M. Coletti Moja, G. Riboldazzi, S. Tunesi, M. Dal Fante, L. Manfredi, M. Lacerenza, R. Cantello, A. Antonini,