Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10746512 | Parkinsonism & Related Disorders | 2005 | 5 Pages |
Abstract
We studied different patterns of deep brain stimulation (DBS), but same average rate, in seven Parkinson disease patients performing a wrist flexion/extension task. Movement times were shorter with regular (continuous) stimulation than cycled 'on' and 'off' for 0.1Â s (mean difference 0.129Â s; 95% confidence interval [CI], 0.228-0.029Â s; P<0.007) and tended to be shorter than cycling at 0.5Â s (mean difference 0.076Â s, 95% CI, 0.171 to â0.020Â s; P<0.6). Movement times under stimulation cycling at 0.5Â s tended to be shorter than cycling at 0.1Â s (mean difference, 0.083Â s, 95% CI, 0.188 to â0.022Â s, P<0.12). Any therapeutic mechanisms of action of DBS must account for patterns of stimulation.
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Authors
Erwin B. Jr.,