| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 107779 | Toxicologie Analytique et Clinique | 2015 | 9 Pages |
Abstract
The presented LC-MSn screening workflow using a combination of spectral library searching of both the Toxtyper and Maurer/Wissenbach/Weber spectral libraries represents a valuable tool for comprehensive and reliable identification of forensically relevant compounds and their metabolites in urine samples. The results of the LC-MSn workflow are in good accordance with results of the gold standard method GC-MS, whilst offering the advantages of a simple sample preparation protocol, usability of glucuronides, sulfates for identification and automated data processing and reporting. Due to their physical “nature” each method reveals a set of drugs which can be detected solely with GC-MS or LC-MSn.
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Authors
B. Schneider, A. Kiehne, M. Meyer, C. Baessmann,