| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10852673 | Biologicals | 2015 | 6 Pages |
Abstract
In summary, Immunate®, Willfact® and Wilate® had lower levels of ADAMTS13 antigen and activity and exhibited a plasma-like VWF triplet structure. Fanhdi® and Haemate HS® had higher ADAMTS13 content and an altered triplet structure. The possible impact of these observations on function and clinical efficacy of VWF/FVIII concentrates is discussed.
Keywords
glycoprotein IbαULVWFTTPvWFFVIIISHPACTVWDHMWADAMTS13VWF:AgVWF:RCovon Willebrand factor antigenFluorescence resonance energy transferFRETvon Willebrand diseaseThrombotic thrombocytopenic purpuraTyrTyrosineVon Willebrand factorcoagulation factor VIIIactivityMethionineMETbody weighthigh molecular weightAntigena disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13
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Authors
Christoph Kannicht, Claudine Fisseau, Werner Hofmann, Mario Kröning, Birte Fuchs,