Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10879891 | Toxicon | 2012 | 10 Pages |
Abstract
The actin cytoskeleton is one of the major targets of bacterial protein toxins. The family of binary actin-ADP-ribosylating toxins, including Clostridium difficile transferase CDT, Clostridium perfringens iota toxin and Clostridium botulinum C2 toxin, modifies arginine-177 of actin. Thereby actin polymerization is blocked. By contrast, actin polymerization is facilitated by the tripartite Photorhabdus luminescens toxin complex including TccC3, which modifies actin at threonine-148. The review discusses both toxin families in respect to recent findings.
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Authors
Klaus Aktories, Carsten Schwan, Panagiotis Papatheodorou, Alexander E. Lang,