| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10879943 | Toxicon | 2012 | 8 Pages |
Abstract
⺠Polymeric 3-alkylpyridinium salts (poly-APS) exert various biological activities by forming large pores in cell membranes. ⺠Poly-APS have direct dose- (1 nM-10 μM) and time-dependent (5-60 min) toxic effects on the cardiovascular system. ⺠Poly-APS diminished vascular function of the isolated rat aorta, and exerted cardiotoxic effects on the isolated rat heart. ⺠Poly-APS showed only minor toxicity in the low concentration range (1-10 nM).
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Authors
Mojca Lunder, Gorazd DrevenÅ¡ek, Simon Hawlina, Kristina SepÄiÄ, Lovro Žiberna,