| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10879976 | Toxicon | 2012 | 8 Pages |
Abstract
⺠Amblyomin-X is a kunitz-type serine protease inhibitor designed from the cDNA library of the Amblyomma cajennense tick. ⺠It inhibits VEGF-A-induced angiogenesis in the subcutaneous tissue of mice and in the chick embryo chorioallantoic membrane. ⺠The mechanism involves impairment on VEGF-A-induced endothelial cell proliferation and adhesions properties. ⺠Inhibition on VEGF-A-induced PECAM-1 endothelial membrane expression may be responsible for the reduced cell adhesion.
Keywords
FACSubiquitin CAmblyomin-XUBCChick embryo Chorioallantoic membraneAmblyomma cajennenseFXaPECAM-1CFSEVEGF-AVEGFR-2APPFITCRT-PCRSPIICAM-1CAMchorioallantoic membraneFactor XaVascular endothelial growth factorfluorescein isothiocyanateFlow cytometryDorsal skinfold chamberserine protease inhibitorsplatelet-endothelial cell adhesion moleculeIntercellular cell adhesion moleculeIntravital microscopyreverse transcription polymerase chain reactionPropidium iodidecarboxyfluorescein diacetate succinimidyl estervascular endothelial growth factor receptor 2
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Authors
C.C. Drewes, R.Y.S. Dias, C.B. Hebeda, S.M. Simons, S.A. Barreto, J.M. Junior, A.M. Chudzinski-Tavassi, S.H.P. Farsky,