| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10879998 | Toxicon | 2012 | 11 Pages |
Abstract
⺠Lonomia obliqua venom induces in vivoendothelial activation increasing l-selectin and VCAM-1 expression. âºÂ L. obliqua venom affects actin cytoskeleton dynamics in endothelial cells. ⺠The venom induces NF-kB activation and increase COX-2, iNOS, HO-1 expression in endothelial cells. ⺠The venom induces a pro-inflammatory profile increasing endothelial MMP-2 and MMP-9 secretion. ⺠The inflammatory effect on vascular endothelium can contribute for local and systemic effects.
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Authors
Vany Nascimento-Silva, Genilson Rodrigues da Silva, João Alfredo Moraes, Fátima Z. Cyrino, Sérgio H. Seabra, Eliete Bouskela, Jorge Almeida Guimarães, Christina Barja-Fidalgo,