| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10880033 | Toxicon | 2012 | 9 Pages |
Abstract
⺠Eight distinct amino acid mutants were prepared and expressed from toxin ErgTx1. ⺠Their binding properties towards the human ERG1 potassium channel were determined. ⺠Amino acids Y14, Y17, F37, M35 are the most important residues for binding. ⺠Additional to these hydrophobic residues K13 is also important. ⺠A 3D-structure model of ErgTX1 was prepared showing this face of the toxin.
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Authors
J.M. Jimenez-Vargas, R. Restano-Cassulini, L.D. Possani,