| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10880051 | Toxicon | 2011 | 10 Pages |
Abstract
⺠Replacement of Glu2, Phe15 and Arg52 by Cys in rStI did not change its conformation. ⺠Substitution of Arg52 by Cys provoked changes in rStI's permeabilizing activity. ⺠Replacement of Glu2 and Phe15 by Cys did not elicit any observable effect. ⺠StI E2C's dimmers stabilized by a disulfide bond enhanced rStI's pore forming ability. ⺠These oligomers linked through their amino termini could facilitate pore formation.
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Authors
A. Valle, A. López-Castilla, L. Pedrera, D. MartÃnez, M. Tejuca, J. Campos, R. Fando, E. Lissi, C. Álvarez, M.E. Lanio, F. Pazos, S. Schreier,