Article ID Journal Published Year Pages File Type
10880069 Toxicon 2012 10 Pages PDF
Abstract
► Intraperitoneal injected MC-LR affected male mice serum hormone level. ► MC-LR induced a decrease in GnRH expression, depend on dose and duration. ► MC-LR increased and then decreased the secretion of FSH, LH and testosterone. ► MC-LR was not able to enter Leydig cells and had no cytotoxicity on Leydig cells. ► MC-LR might significant damage both hypothalamus and pituitary.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry, Genetics and Molecular Biology (General)
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Microcystin (-LR) affects hormones level of male mice by damaging hypothalamic-pituitary system
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