Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10880114 | Toxicon | 2012 | 4 Pages |
Abstract
Mice experimentally envenomed with Hypnale hypnale venom (1Ã and 1.5Ã LD50) developed acute kidney injury (AKI) principally characterized by raised blood urea and creatinine. Prolonged blood clotting time and hemorrhage in lungs implied bleeding tendency. Pallor noted in most renal cortices was suggestive of renal ischemia secondary to consumptive coagulopathy. Intravenous infusion of Hemato polyvalent antivenom following experimental envenoming effectively prevented death and AKI in all mice, supporting its potential therapeutic use in envenoming cases.
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Authors
Choo Hock Tan, Nget Hong Tan, Si Mui Sim, Shin Yee Fung, Pailoor Jayalakshmi, Christeine Ariaranee Gnanathasan,