High-resolution picture of a venom gland transcriptome: Case study with the marine snail Conus consors

► We used high throughput technology at the transcriptomic level to get a complete view of a cone snail venom duct transcriptome. ► We discovered new conopeptide families and new scaffolds. ► We observed dramatic variation of transcription level between the different isoforms. ► Beyond conopeptides, this study provides new highlights on the compounds which could play a role in the venom function. ► From this point, we could expand the definition of the cone snail's venoms.