Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10880215 | Toxicon | 2012 | 5 Pages |
Abstract
We show that BJcuL, a lectin purified from Bothrops jararacussu venom, exerts cytotoxic effects to gastric carcinoma cells MKN45 and AGS. This effect was due to the direct interaction with specific glycans on the cells surface and was observed by cell viability decrease, disorganization of actin filaments and apoptosis. In addition, BJcuL was able to reduce tumor cell adhesion to matrigel, what was inhibited by specific carbohydrate or partially inhibited when cells were pre-incubated with matrigel. Our results suggest that BJcuL was able to promote apoptosis in both tumor cells lines and therefore has a prospect for potential use in cancer therapy.
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Authors
Stefanie Nolte, Danusa de Castro Damasio, Adriana Cristina Baréa, Joana Gomes, Ana Magalhães, Luciana F.C. Mello Zischler, PatrÃcia M. Stuelp-Campelo, Selene L. ElÃfio-Esposito, Maria Cristina Roque-Barreira, Celso A. Reis,