| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10880220 | Toxicon | 2012 | 7 Pages |
Abstract
⺠We simulated in mice, catecholamine rise of Tityus zulianus (TZ)-envenomed patients. ⺠TZ venom increased in 4000%, the plasma catecholamine (Epinephrine) levels in mice. ⺠Plasma levels of MHPG (main Epi-catabolite) were also increased in TZ-envenomed mice. ⺠TZ venom potentiated the dopamine release from PC12 cells (PC12) by carbamylcholine. ⺠Dopamine release by TZ at PC12 is hexamethonium-insensitive suggesting novel toxins.
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Authors
Ernesto Trejo, Adolfo Borges, Betty Nañez, Itala Lippo de Becemberg, Ramona González de Alfonzo, Marcelo J. Alfonzo,