Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10880787 | Toxicon | 2011 | 9 Pages |
Abstract
Furthermore, 42-OH-PLTX induced in vitro delayed erythrocyte hemolysis at concentrations similar to those of PLTX (EC50Â =Â 7.6 and 13.2Â ÃÂ 10â12Â M, respectively). This hemolysis could be completely neutralized by a monoclonal anti-PLTX antibody. The in vivo data, together with the in vitro data recorded for 42-OH-PLTX, seem to indicate Na+/K+-ATPase as one of the key cellular targets of this toxin.
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Authors
A. Tubaro, G. Del Favero, D. Beltramo, M. Ardizzone, M. Forino, M. De Bortoli, M. Pelin, M. Poli, G. Bignami, P. Ciminiello, S. Sosa,