Article ID Journal Published Year Pages File Type
10882950 Mitochondrion 2012 9 Pages PDF
Abstract
► Delivery of functional DNA/RNA to mitochondria in vivo has not been observed. ► Using a carrier complex, polycistronic RNAs were delivered to various rat tissues. ► This resulted in the improvement of the respiratory capacity of skeletal muscle. ► The effect was most pronounced in the 14-mo group but less in the 24 mo group.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biophysics
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Modulation of mitochondrial respiratory capacity by carrier-mediated transfer of RNA in vivo
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