Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10882969 | Mitochondrion | 2013 | 5 Pages |
Abstract
To achieve mitochondrial therapy, we previously reported on the use of an octaarginine (R8) modified Dual Function (DF)-MITO-Porter for delivering molecules to mitochondria in living cells. In this study, using isolated mitochondria, homogenates and living cells, we evaluated the utility of mitochondrial targeting functional peptides as a ligand for delivering carriers. The S2 peptide modified carrier showed a high mitochondrial targeting activity in homogenates and living cells. In addition, the S2 peptide had a lower cell toxicity compared to R8 modified liposomes. The S2 peptide represents a potentially useful moiety for constructing an efficient and safe mitochondrial delivery system.
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Authors
Eriko Kawamura, Yuma Yamada, Hideyoshi Harashima,