| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10882981 | Mitochondrion | 2013 | 16 Pages |
Abstract
⺠C. elegans SIRT4 orthologs function during oxidative stress in mitochondria. ⺠Conserved interaction of SIRT4 with mitochondrial biotinâdependent carboxylases. ⺠All three carboxylases are acetylated on multiple lysine residues. ⺠Acetylation of K748 changed the enzymatic activity of pyruvate carboxylase (PC). ⺠No deacetylation or regulation of PC by SIRT4 in liver and HEK293 cells was found.
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Authors
Martina Wirth, Samir Karaca, Dirk Wenzel, Linh Ho, Daniel Tishkoff, David B. Lombard, Eric Verdin, Henning Urlaub, Monika Jedrusik-Bode, Wolfgang Fischle,