Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac myocytes

Article ID	Journal	Published Year	Pages	File Type
10883112	Mitochondrion	2012	10 Pages	PDF

Abstract

âº We synthesized recombinant human TFAM protein. âº Recombinant human TFAM functioned to increase mtDNA copy number in cardiac myocytes. âº Recombinant human TFAM inhibited NFAT signaling. âº Recombinant human TFAM attenuated pathological hypertrophy of cardiac myocytes.

Keywords

NFAT succinate dehydrogenase complex subunit A RPL27 MCIP1 Ribosomal protein L27 sdhA Hprt ATIII ANGII TFAM BNP ET-1 MTS Cytochrome c oxidase I ERK GST Mitochondrial DNA MAPK ROS antithrombin III Myocardial infarction Angiotensin II endothelin-1 mtDNA mitochondrial targeting signal mitochondrial transcription factor A Nuclear Factor of Activated T Cells NDUFA9 Cardiac hypertrophy hypoxanthine guanine phosphoribosyl transferase mitogen-activated protein kinase brain natriuretic peptide Cox I extracellular signal-regulated kinase glutathione S-transferase Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biophysics

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Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac myocytes

Authors

Takeo Fujino, Tomomi Ide, Masayoshi Yoshida, Ken Onitsuka, Atsushi Tanaka, Yuko Hata, Motohiro Nishida, Takako Takehara, Takaaki Kanemaru, Naoyuki Kitajima, Shinya Takazaki, Hitoshi Kurose, Dongchon Kang, Kenji Sunagawa,