| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10883123 | Mitochondrion | 2013 | 48 Pages |
Abstract
⺠Edelfosine and perifosine inhibit hepatic mitochondrial respiration. ⺠Both compounds induce the mitochondrial permeability transition (MPT). ⺠Edelfosine decreases H2O2 production by the respiratory chain. ⺠This work demonstrates direct mitochondrial effects of both compounds.
Keywords
antimycin ARCRΔΨmFCCPMPTBSAEdelfosineTPP+bovine serum albuminalkylphospholipidsmitochondrial permeability transitionCSAanalysis of varianceANOVAstandard error of the meanAlpsRotRotenoneToxicitycyclosporin Aendoplasmic reticulumSEMRatMitochondriarespiratory control ratiomitochondrial transmembrane electric potentialPerifosinetetraphenylphosphonium cationLivercarbonyl cyanide p-trifluoromethoxyphenylhydrazone
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Authors
Ana Burgeiro, Cláudia V. Pereira, Filipa S. Carvalho, Gonçalo C. Pereira, Faustino Mollinedo, Paulo J. Oliveira,