Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10883138 | Mitochondrion | 2012 | 11 Pages |
Abstract
The link between sirtuin activity and mitochondrial biology has recently emerged as an important field. This conserved family of NAD+-dependent deacetylase proteins has been described to be particularly involved in metabolism and longevity. Recent studies on protein acetylation have uncovered a high number of acetylated mitochondrial proteins indicating that acetylation/deacetylation processes may be important not only for the regulation of mitochondrial homeostasis but also for metabolic dysfunction in the context of various diseases such as metabolic syndrome/diabetes and cancer. The functional involvement of sirtuins as sensors of the redox/nutritional state of mitochondria and their role in mitochondrial protection against stress are hereby described, suggesting that pharmacological manipulation of sirtuins is a viable strategy against several pathologies.
Keywords
SOD2HFDPPARγBERADPSIRTsirtuinMPTPMEFsMnSODPGC-1αUCP2CREBSirtuinsSir2CPS1Cyclophilin DHIF1αpoly [ADP-ribose] polymerase 1DNA-PKCypDHMGCS2LCADTNFAMPKGDHACCOTCDSBHDLPARP-1MPPANTOSCCperoxisome proliferator-activated receptor gamma coactivator 1-alphahigh-density lipoproteinNAD+ROSATPadenosine diphosphateAIFacetyl-CoA carboxylaseacetyl-coenzyme AAcetyl-CoAcAMP response element-bindingmitochondrial permeability transition poreornithine transcarbamoylaseFatty acid oxidationadenine nucleotide translocatorbase excision repairOxidative stressforkhead Box OHigh fat dietToxicologymanganese superoxide dismutaseSuperoxide dismutase 2double-strand breakapoptosis-inducing factorFAOtumor necrosis factorFoxOMetabolismcalorie restrictionNDUFA9mouse embryonic fibroblastsMitochondrianicotinamide adenine dinucleotidehistone 4DNA-dependent protein kinasemitochondrial processing peptidaseuncoupling protein 25′ adenosine monophosphate-activated protein kinaseoral squamous cell carcinomaglutamate dehydrogenaseReactive oxygen speciesEstrogen-related receptor alphaperoxisome proliferator-activated receptor
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biophysics
Authors
Claudia V. Pereira, Magda Lebiedzinska, Mariusz R. Wieckowski, Paulo J. Oliveira,