Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10883158 | Mitochondrion | 2011 | 8 Pages |
Abstract
A constitutive knockout (KO) mouse for Surf1 enables invasive investigations of distinct aspects of LS. In the present study the respiratory function was analyzed applying an arterially perfused brainstem preparation. Compared to wild type (WT) preparations Surf1 KO preparations had a higher baseline respiratory frequency and abnormal responses to hypoxia and hypercapnia that involved both respiratory frequency and motor nerve discharge pattern. These data suggest that COX deficiency impairs peripheral and/or central chemoreceptor function.
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Authors
Georg M. Stettner, Carlo Viscomi, Massimo Zeviani, Ekkehard Wilichowski, Mathias Dutschmann,