Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10883615 | Progress in Biophysics and Molecular Biology | 2011 | 14 Pages |
Abstract
This paper presents a contribution to the definition of the interfaces required to perform heterogeneous model integration in the context of integrative physiology. A formalization of the model integration problem is proposed and a coupling method is presented. The extension of the classic Guyton model, a multi-organ, integrated systems model of blood pressure regulation, is used as an example of the application of the proposed method. To this end, the Guyton model has been restructured, extensive sensitivity analyses have been performed, and appropriate transformations have been applied to replace a subset of its constituting modules by integrating a pulsatile heart and an updated representation of the renin-angiotensin system. Simulation results of the extended integrated model are presented and the impacts of their integration within the original model are evaluated.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biophysics
Authors
Alfredo I. Hernández, Virginie Le Rolle, David Ojeda, Pierre Baconnier, Julie Fontecave-Jallon, François Guillaud, Thibault Grosse, Robert G. Moss, Patrick Hannaert, S. Randall Thomas,