Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10883788 | Advanced Drug Delivery Reviews | 2005 | 12 Pages |
Abstract
Evaluation of mucoadhesive property of polymer-coated particulate systems was demonstrated with the particle counting method developed by us. To detect the mucoadhesive phenomena in the intestinal tract, we observed the rat intestine with the confocal laser scanning microscope (CLSM) after oral administration of the particulate systems. The resultant photographs clearly showed a longer retention of submicron-sized chitosan-coated liposomes (ssCS-Lip) in the intestinal tract than other liposomal particles tested such as non-coated liposomes and chitosan-coated multilamellar one. These observations explained well the superiority of the ssCS-Lip as drug carrier in oral administration of calcitonin in rats than other liposomal particles.
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Authors
Hirofumi Takeuchi, Jringjai Thongborisute, Yuji Matsui, Hikaru Sugihara, Hiromitsu Yamamoto, Yoshiaki Kawashima,