Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10883913 | Advanced Drug Delivery Reviews | 2005 | 10 Pages |
Abstract
Embryonic stem cells offer enormous potential as a source of a variety of differentiated cells for cell therapy, drug discovery and toxicology screening. With the creation of human embryonic stem cell lines we now have a resource with the potential to differentiate into every tissue of the body. To fully harness this resource it is necessary to understand their biology. Here we give a background to their history, describe interesting elements of their cell biology and introduce the underlying signalling mechanisms that control their ability to self-renew and differentiate.
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Authors
Ruairi Friel, Sjaak van der Sar, Patrick J. Mee,