Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10883972 | Advanced Drug Delivery Reviews | 2005 | 22 Pages |
Abstract
The heightened concerns about bioterrorism and the use of biowarfare agents have prompted substantial increased efforts towards the development of vaccines against a wide range of organisms, toxins, and viruses. An increasing variety of platforms and strategies have been analyzed for their potential as vaccines against these agents. DNA vectors, live-attenuated viruses and bacteria, recombinant proteins combined with adjuvant, and viral- or bacterial-vectored vaccines have been developed as countermeasures against many potential agents of bioterrorism or biowarfare. The use of viruses, for example adenovirus, vaccinia virus, and Venezuelan equine encephalitis virus, as vaccine vectors has enabled researchers to develop effective means for countering the threat of bioterrorism and biowarfare. An overview of the different viral vectors and the threats they counter will be discussed.
Keywords
UTRRVFVVSVHFRSEBOVHTNVVEEVSEBRCNSINVHPSNHPBoNTTRDBWCSFVVHFOVANIAIDKBPVRPFDALSVRaccoon poxvirusBiological and toxin weapons conventionAdenovirusProtective antigenStaphylococcal enterotoxin BconViral vectorsBioterrorismHemorrhagic fever with renal syndromeViral hemorrhagic feverchicken ovalbuminELISAEnzyme-linked immunosorbent assaythymidine kinasekilobase pairsBiodefenseFood and Drug Administrationuntranslated regionNational Institute of Allergy and Infectious DiseasesBotulinum neurotoxinNucleoproteinplaque forming unitsVaccineLassa virusPuumala virusSemliki Forest virusSindbis virusVesicular stomatitis virusVenezuelan equine encephalitis virusRift Valley fever virusSeoul virusMarburg virusHIVhuman immunodeficiency virusRabies virusHantaan virusvaccinia virusNonhuman primatepfuPUUVCapsidkilobasesGlycoprotein
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biotechnology
Authors
John S. Lee, Angela G. Hadjipanayis, Michael D. Parker,