Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10884611 | Biosystems | 2012 | 4 Pages |
Abstract
Here minimization of kinetic energy disturbances during protein evolution by mutation allows an optimization of the genetic code to be highlighted. The quadratic forms corresponding to the kinetic energy term are considered over the field of rational numbers. Arguments are given to support the introduction of notions from basic number theory within this context. The observations found to be consistent with this minimization are statistically significant. The genetic code may well have been optimized according to energetic criteria so as to improve folding and dynamic properties of polypeptide chains.
Related Topics
Physical Sciences and Engineering
Mathematics
Modelling and Simulation
Authors
Antonin Guilloux, Jean-Luc Jestin,