| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10884726 | Biosystems | 2005 | 9 Pages |
Abstract
A simple mathematical approach to the cooperativity in RMs formed by dimers of identical receptors and/or by iso-receptors is proposed. To this aim the so-called “symmetry rule” has been considered. This approach allows to describe by means of a simple energy function the effects of receptor composition (number of dimers), spatial organisation (respective location of the dimers) and order of activation (order according to which the single receptors are ligated) on the integrative cooperativity (index) of the RMs.
Related Topics
Physical Sciences and Engineering
Mathematics
Modelling and Simulation
Authors
Luigi F. Agnati, Alexander O. Tarakanov, Diego Guidolin,