Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10885690 | Drug Discovery Today | 2016 | 31 Pages |
Abstract
The rapid assembly and in situ screening of focused combinatorial fragment libraries using CuAAC click chemistry is a highly robust and efficient strategy for establishing SAR and for discovering bioactive molecules. This review outlines the current status of this methodology in drug discovery application. The inherent limitations, challenges and prospects are critically discussed.
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Authors
Xueshun Wang, Boshi Huang, Xinyong Liu, Peng Zhan,