Article ID Journal Published Year Pages File Type
10885690 Drug Discovery Today 2016 31 Pages PDF
Abstract
The rapid assembly and in situ screening of focused combinatorial fragment libraries using CuAAC click chemistry is a highly robust and efficient strategy for establishing SAR and for discovering bioactive molecules. This review outlines the current status of this methodology in drug discovery application. The inherent limitations, challenges and prospects are critically discussed.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biotechnology
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