Split protein biosensor assays in molecular pharmacological studies

- Split biosensor assays allow monitoring of dynamic protein-protein interactions in cell-based assays.
- The activity of druggable targets, such as GPCRs and RTKs, can be sensitively and robustly assessed.
- Readouts include bioluminescence, fluorescence and adaptable transcriptional reporters.
- Split biosensor assays are amenable to cell-based high-throughput formats and animal models.
- Transcription-based molecular barcoding techniques enable applications in multiplexed cell-based assays.