Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10885838 | Drug Discovery Today | 2014 | 6 Pages |
Abstract
Appreciation for the resolution of inflammation has increased in recent years, with the detailing of specific mediators and pathways and the identification of (receptor) targets that could be exploited for innovative anti-inflammatory drug discovery programmes. Thus, acute inflammation resolves by the intervention of endogenous anti-inflammatory mediators that reduce white blood cell recruitment and promote removal of migrated leukocytes by apoptosis and phagocytosis by resident 'cleaners', such as the macrophages, resulting ultimately in the repair of the inflamed or injured tissue. Here, we explore a selection of pro-resolving proteinaceous mediators and targets, such as melanocortins and galectins.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biotechnology
Authors
Tazeen J. Ahmed, Magdalena K. Kaneva, Costantino Pitzalis, Dianne Cooper, Mauro Perretti,