| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10885850 | Drug Discovery Today | 2014 | 6 Pages |
Abstract
Pulmonary arterial hypertension (PAH) is a progressive disease that involves pathological remodeling, vasoconstriction and thrombosis. Alterations in hemostasis, coagulation and platelet activation are consistently observed in PAH patients. Microparticles derived from platelets, inflammatory cells and the endothelium are an increasingly well-recognized signal in a variety of cardiovascular diseases, including PAH. This review will focus on the roles of coagulation, thrombosis, platelet activation and microparticles in the pathology and progression of PAH.
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Authors
Katie L. Lannan, Richard P. Phipps, R. James White,