| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10885864 | Drug Discovery Today | 2015 | 16 Pages |
Abstract
- High content analysis (HCA) gives fluorescent imaging data on cell parameters in live cells.
- HCA is now used in to monitor sub-lethal cellular toxicology of drug delivery vehicles.
- Data on permeation enhancers, polymers and nanoparticles is reviewed.
- The data yields quantitative detailed information from up to 72Â hour cell exposures.
- HCA also tracks nanoparticle intracellular routing in cells and siRNA can dissect pathways.
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Authors
David J. Brayden, Sally-Ann Cryan, Kenneth A. Dawson, Peter J. O'Brien, Jeremy C. Simpson,