| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10885880 | Drug Discovery Today | 2015 | 19 Pages |
Abstract
The recently developed ability to differentiate primary adult stem cells and induced pluripotent stem cells (iPSCs) into cardiomyocytes is providing unprecedented opportunities to produce an unlimited supply of cardiomyocytes for use in patients with heart disease. Here, we examine the evidence for the preclinical use of such cells for successful heart regeneration. We also describe advances in the identification of new cardiac molecular and cellular targets to induce proliferation of cardiomyocytes for heart regeneration. Such new advances are paving the way for a new innovative drug development process for the treatment of heart disease.
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Authors
Marie Wegener, Augustinus Bader, Shibashish Giri,