| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10885907 | Drug Discovery Today | 2015 | 9 Pages |
Abstract
Urocortin (Ucn)-2 - corticotropin-releasing hormone receptor 2 signaling has favorable effects in the cardiovascular system, including coronary vasodilatation, with increased coronary blood flow and conductance and augmented cardiac contractility and output, as well as protection against ischemia/reperfusion injury. Indeed, several animal studies have confirmed the salutary therapeutic effects of Ucn-2 in chronic heart failure, with improvements in cardiac performance and animal survival. In addition, recent clinical trials have demonstrated the benefits of Ucn-2 in patients with stable chronic heart failure on optimal medical therapy.
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Authors
Rui Adão, Diana Santos-Ribeiro, Miriam T. Rademaker, Adelino F. Leite-Moreira, Carmen Brás-Silva,