Intracellular caspase-modulating chimeric antigen receptor

- Intracellular agent targets mutant proteins and induces apoptosis.
- Chimera with a targeting domain, a molecular switch and a pro-apoptotic effector.
- A constitutively active caspase-3 mutant (V266E), efficient at low concentrations.
- Engineered mAb or zinc finger targeting tumor-specific mutations.
- Inteins provide flexible platform for control of protein function.