| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10886111 | Drug Discovery Today | 2014 | 4 Pages |
Abstract
- We describe the analysis of 70 years of mouse TB in vivo data.
- We visualize a 'valley of death' of approximately 40 years in TB research.
- We provide suggestions of how to prioritize the 1000s of in vitro hits.
- We suggest the need for more in vivo testing in mice.
- The machine learning model approach used with this in vivo data may be applicable to other datasets.
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Authors
Sean Ekins, Eric L. Nuermberger, Joel S. Freundlich,