Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10886198 | Drug Discovery Today | 2005 | 8 Pages |
Abstract
This review of high throughput (HT) P450 inhibition technologies and their impact on early drug discovery finds the field at a mature stage. The relationship between P450 inhibition and drug-drug interactions is well understood. A wide variety of P450 inhibition detection technologies are readily available off-the-shelf, but what seems still to be missing is a general agreement on how much weight one should give to the various types of early discovery HT P450 inhibition data. Method-dependent potency differences are a cause of concern, and to resolve this issue the authors advocate calibration of the HT methods with a large set of marketed drugs.
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Authors
Gregor Zlokarnik, Peter D.J. Grootenhuis, John B. Watson,