Article ID Journal Published Year Pages File Type
10886270 Drug Discovery Today 2005 7 Pages PDF
Abstract
Despite recent technological advances, the analysis of biological samples for metabolite identification purposes often requires prior knowledge of the metabolite masses to successfully acquire high quality mass spectral data in the presence of intense background and interfering matrix signals. This, in turn, necessitates prior knowledge of the metabolite structure, which in most cases can be predicted on the basis of the potential routes of metabolism of those functional groups present in the molecule. The following discussion highlights the significance of knowledge of the metabolite mass in facilitating the detection and structural elucidation of drug metabolites.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biotechnology
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