Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10886809 | Drug Discovery Today | 2005 | 7 Pages |
Abstract
Protein therapeutics, including monoclonal antibodies, are a growing focus of drug discovery research organizations. High-throughput screening of large libraries of protein variants is therefore becoming increasingly important in R&D. As a result, there is a need to link large numbers of variant protein sequences with chemical and biological assay data. This integration will allow more efficient data mining and facilitate decision-making regarding hit identification, lead optimization and drug development. In this paper, we present an implementation in which a widely used small-molecule high-throughput screening data management system has been adapted to meet the unique needs of protein drug discovery and development.
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Authors
Jost Vielmetter, Jeff Tishler, Marie L. Ary, Peter Cheung, Richard Bishop,