Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10895543 | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2016 | 45 Pages |
Abstract
The development of oncoprotein-targeted anticancer drugs is an invaluable weapon in the war against cancer. However, cancers do not give up without a fight. They may develop multiple mechanisms of drug resistance, including apoptosis inhibition, drug expulsion, and increased proliferation that reduce the effectiveness of the drug. The collective work of researchers has highlighted the role of cytokines in the mechanisms of cancer drug resistance, as well as in cancer cell progression. Furthermore, recent studies have described how specific cytokines secreted by cancer stromal cells confer resistance to chemotherapeutic treatments. In order to gain a better understanding of mechanism of cancer drug resistance and a prediction of treatment outcome, it is imperative that correlations are established between global cytokine profiles and cancer drug resistance. Here we discuss the recent discoveries in this field of research and discuss their implications for the future development of effective anti-cancer medicines.
Keywords
NGALSDF-1FGFMcl-1CMLBclTGFECMCCLGEMPARPHGFTKIPI3PSCsmRCCTNFAMLphosphoinositide 3STAT3BCRAMFMMPHER2MDREGFMyeloid cell leukemia-1PFsadrenomedullinAntibody arrayMultiplex immunoassayinterleukinprogression-free survivaltransforming growth factorregulated on activation, normal T cell expressed and secretedEMTstromal cellsPancreatic Stellate CellsCytokineGranulocyte colony stimulating factorepidermal growth factorHepatocyte growth factorstromal cell-derived factor-1Autocrine motility factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)fibroblast growth factorG-CSFtumor necrosis factorB-cell lymphomaacute myeloid leukemiaChronic myeloid leukemianeutrophil gelatinase-associated lipocalinExtracellular matrixmatrix metalloproteinasesignal transducer and activator of transcription 3RANTESbone marrowCancer drug resistanceMultidrug resistancebreakpoint cluster regionTyrosine kinase inhibitorTumor microenvironmentpoly ADP-ribose polymeraseMetastatic renal cell carcinomaEpithelial–mesenchymal transitionHuman epidermal growth factor receptor 2
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Valerie Sloane Jones, Ren-Yu Huang, Li-Pai Chen, Zhe-Sheng Chen, Liwu Fu, Ruo-Pan Huang,