Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10895572 | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2014 | 11 Pages |
Abstract
The new frontier of inhibiting the mTOR pathway is to identify agents targeting the feedback loops and cross talks with other pathways involved in the acquired resistance to mTOR inhibitors. The true goal will be to identify biomarkers predictive of sensitivity or resistance to efficiently develop novel agents with the aim to avoid toxicities and to better choose the active drug for the right patient.
Keywords
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Cancer Research
Authors
Matteo Santoni, Francesco Pantano, Consuelo Amantini, Massimo Nabissi, Alessandro Conti, Luciano Burattini, Alice Zoccoli, Rossana Berardi, Giorgio Santoni, Giuseppe Tonini, Daniele Santini, Stefano Cascinu,