The role of key genes and pathways involved in the tumorigenesis of Malignant Mesothelioma

The involvement of key genes and their respective proteins in the development of MM. The proteins p16INK4a and p14ARF are involved in pRb pathway activation and in p53 modulation, respectively. The NF2 encodes the protein Merlin, LAST2 encodes the protein LAST2, β-catenin is encoded by CTNNB1 and SAV encodes the protein SAV, thus these proteins play an important role in the hippo pathway. BAP-1 encodes the protein BAP-1 that plays an important role in DNA damage response and in cell cycle control. The genes Cry, Per and Bmal-1 are key players responsible for regulating the circadian rhythm control.212